microRNA调控动物毛色和肤色的研究进展

doi:10.11843/j.issn.0366-6964.2016.06.002

摘要/Abstract

摘要：

黑色素细胞对于毛色和肤色的形成具有至关重要的作用。黑色素细胞由胚胎时期的神经嵴干细胞分化而来，在成熟黑色素细胞内通过一系列复杂的酶催化反应最终生成黑色素，从而决定动物的毛色和肤色。黑色素的生成过程复杂，受到一些转录因子、激素、信号通路分子协同调控。microRNA(miRNA)是一类长约22 nt的内源性非编码RNA，主要通过抑制转录后的翻译过程来调控基因表达。越来越多的研究表明，miRNA与黑色素生成相关。本文对黑色素沉积相关的miRNAs的挖掘和鉴定工作以及miRNAs调控毛色和肤色的研究进展进行综述。

Abstract:

Melanocyte，generated from embryonic neural crest stem cells，plays important roles in coat and skin color formation.Melanin，the product of a series of enzyme catalyzed reactions in melanocyte，determines animal coat and skin color.Melanogenesis is a complex process involving coordinated regulation of some transcription factors，hormones and signaling pathway molecules.microRNA (miRNA) is a class of endogenous，non-coding，small RNA molecule (about 22 nt)，which regulates gene expression mainly at the post-transcription level.More and more evidences demonstrated that miRNA involve in the regulation of melanogenesis.Herein，it was reviewed in this paper the studies on the discovery and identification of melanin-associated miRNAs，and the research progress of how miRNAs regulate animal coat and skin color.

中图分类号:

Q343

巫小倩，刘辰东，堵晶晶，罗嘉，朱砺，张顺华. microRNA调控动物毛色和肤色的研究进展[J]. 畜牧兽医学报, 2016, 47(6): 1086-1092.

WU Xiao-qian，LIU Chen-dong，DU Jing-jing，LUO Jia，ZHU Li，ZHANG Shun-hua. Research Progress of the Role of microRNAs in the Regulation of Animal Coat and Skin Color[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(6): 1086-1092.

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https://www.xmsyxb.com/CN/Y2016/V47/I6/1086

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